Hemorrhagic hypotension increases plasma beta‐endorphin concentrations in the nonhuman primate
作者:
BART CHERNOW,
C. LAKE,
STEVEN TEICH,
EDWARD MOUGEY,
JAMES MEYERHOFF,
LARRY CASEY,
J. FLETCHER,
期刊:
Critical Care Medicine
(OVID Available online 1986)
卷期:
Volume 14,
issue 5
页码: 505-507
ISSN:0090-3493
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
The role which beta-endorphin plays in the pathogenesis of hemorrhagic hypotension is controversial. In the present experiment, 20 ml/kg of blood was bled from ten healthy male baboons (Papio anubis) over 60 min and then retransfused over the next 30 min. We found that the mean plasma beta-endorphin level increased 109% above baseline (p< .05) within 15 min after starting hemorrhage, and rapidly returned to a baseline concentration with retransfusion. We conclude that in a primate species, circulating endogenous opioid peptide concentrations increase rapidly in response to sublethal hemorrhagic hypotension and normalize with restoration of the baseline intravascular volume. These findings support the concept that endogenous opioid peptides may mediate the hypotension of shock states.
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