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A new synthesis of Rink's polymer, 4‐(2′,4′‐dimethoxyphenylhydroxymethyl) phenoxymethylpolystyrene

 

作者: GYÖRGYI VÁRADI,   GÁBOR K. TÓTH,   BOTOND PENKE,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1994）
卷期: Volume 43, issue 1  

页码: 29-30

 

ISSN:0367-8377

 

年代: 1994

 

DOI:10.1111/j.1399-3011.1994.tb00372.x

 

出版商: Blackwell Publishing Ltd

 

关键词: 2,4‐dimethoxy‐4′‐hydroxybenzhydrol;potassium salt coupling of phenolate;side reactions;substitution level

 

数据来源: WILEY

 

摘要:

For solid‐phase peptide synthesis, 2, 4‐dimethoxy‐4′ ‐hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2, 4‐dimethoxy‐4′‐hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degre

 

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