首页   按字顺浏览 期刊浏览 卷期浏览 Discontinuation of maintenance therapy for cytomegalovirus retinitis in HIV-infected pa...
Discontinuation of maintenance therapy for cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy

 

作者: Marc Jouan,   Marianne Savès,   Roland Tubiana,   Guislaine Carcelain,   Nathalie Cassoux,   Camille Aubron-Olivier,   Anne-Marie Fillet,   Maryem Nciri,   Brigitte Sénéchal,   Geneviève Chêne,   Christina Tural,   Stéphane Lasry,   Brigitte Autran,   Christine Katlama,  

 

期刊: AIDS  (OVID Available online 2001)
卷期: Volume 15, issue 1  

页码: 23-31

 

ISSN:0269-9370

 

年代: 2001

 

出版商: OVID

 

数据来源: OVID

 

摘要:

ObjectiveTo study the safety of discontinuing cytomegalovirus (CMV) maintenance therapy among patients with cured CMV retinitis receiving highly active antiretroviral therapy (HAART).MethodsPatients with a history of CMV retinitis who were receiving anti-CMV maintenance therapy and who had a CD4 cell count > 75 × 106cells/l and a plasma HIV RNA level < 30 000 copies/ml while on HAART were included in a multicentre prospective study. Maintenance therapy for CMV retinitis was discontinued at enrolment and all the patients were monitored for 48 weeks by ophthalmological examinations and by determination of CMV markers, CD4 cell counts and plasma HIV RNA levels. T helper-1 anti-CMV responses were assessed in a subgroup of patients. The primary study endpoint was recurrence of CMV disease.ResultsAt entry, the 48 assessable patients had been taking HAART for a median of 18 months. The median CD4 cell count was 239 × 106cells/l and the median HIV RNA load was 213 copies/ml. Over the 48 weeks, 2 of the 48 patients had a recurrence of CMV disease. The cumulative probability of CMV retinitis relapse was 2.2% at week 48 (95% confidence interval, 0.4–11.3) and that of all forms of CMV disease 4.2%. CMV blood markers remained negative throughout follow-up. The proportion of patients with CMV-specific CD4 T cell reactivity was 46% at baseline and 64% at week 48.ConclusionsCMV retinitis maintenance therapy may be safely discontinued in patients with CD4 cell counts above 75 × 106cells/l who have been taking HAART for at least 18 months.

 

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