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Gm Haplotypes in Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Japanese Patients

 

作者: Takeshi Yasuda,   Gen Sobue,   Kazuhiko Kumazawa,   Masayuki Baba,   Toyokazu Saitoh,   Tsutomu Yanagi,   Terunori Mitsuma,   Tokiko Miyazaki,  

 

期刊: European Neurology  （Karger Available online 1994）
卷期: Volume 34, issue 4  

页码: 221-223

 

ISSN:0014-3022

 

年代: 1994

 

DOI:10.1159/000117042

 

出版商: S. Karger AG

 

关键词: Chronic inflammatory demyelinating polyradiculoneuropathy;Gm haplotype;Gm phenotype;Immunoglobulin heavy chain;HLA

 

数据来源: Karger

 

摘要:

We studied the serum Gm allotype of 58 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and 236 nonrelated normal controls in Japan. The incidences of the Gm phenotype and haplotype in the patients were not significantly different from those in the normal controls. When CIDP was classified into two subgroups in terms of clinical course, the chronic relapsing (CR) and chronic nonrelapsing type (CNR), the distribution of all Gm haplotypes was significantly different between CR and CNR (total X2= 8.319; corrected p < 0.05). Our findings suggest that the clinical course of CIDP may be associated with the Gm haplotype.

 

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