REMODELLING OF THE VASCULAR SYSTEM IN RESPONSE TO HYPERTENSION AND DRUG THERAPY
作者:
B. I. Levy,
M. E. Safar,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1992)
卷期:
Volume 19,
issue S19
页码: 33-37
ISSN:0305-1870
年代: 1992
DOI:10.1111/j.1440-1681.1992.tb02808.x
出版商: Blackwell Publishing Ltd
关键词: angiotensin‐converting enzyme inhibitor;hypertension;perindopril;vascular remodelling;vascular wall
数据来源: WILEY
摘要:
SUMMARY1. Arterial remodelling is an important mechanism in the pathophysiology of hypertension and its complications, being involved in the decrease of vascular reserve, the autoregulation of cerebral blood flow and the development of atherosclerosis. There is now evidence that, in addition to several other growth factors, vasoactive peptides such as angiotensin II may act as vascular smooth muscle growth‐promoting substances. Based on these data, the effects of perindopril, a potent and long‐lasting angiotensin‐converting enzyme (ACE) inhibitor, on structural and mechanical properties of the arterial wall have been studied in animal models of hypertension. Perindopril completely reversed the aortic medial hypertrophy and arterial stiffening observed in renovascular hypertensive rats and in spontaneously hypertensive rats. The effect of perindopril was consistent with the potent inhibition of vascular ACE, and emphasized the potential role of angiotensin II as a vascular growth modulator. Whether the time constant of remodelling is similar or not in the heart and large vessels remains an important question that requires further investig
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