Localization of endothelin‐like immunoreactivity in airway epithelium of rats and mice
作者:
Nora Rozengurt,
David R. Springall,
Julia M. Polak,
期刊:
The Journal of Pathology
(WILEY Available online 1990)
卷期:
Volume 160,
issue 1
页码: 5-8
ISSN:0022-3417
年代: 1990
DOI:10.1002/path.1711600104
出版商: John Wiley&Sons, Ltd.
关键词: Rat;mouse;lung;respiratory epithelium;endothelin;immunocytochemistry
数据来源: WILEY
摘要:
AbstractWe have examined lungs from adult Wistar rats (n= 6) and four different strains of juvenile and adult mice (n= 40) to localize endothelin‐like immunoreactivity. Paraffin sections of lung tissue fixed by distension in Bouin's fluid were stained by the peroxidase–antiperoxidase (PAP) method using 10 different rabbit antisera to endothelin. Immunoreactivity was detected in the majority of epithelial cells of conducting airways from the hilum to the periphery and was similar in rats and all four strains of mice studied. Intense immunostaining was detected in mucous, serous and Clara cells and in occasional alveolar pneumocytes type II. Basal cells and most ciliated cells did not immunostain. From these results it is concluded that endothelin‐like immunoreactivity is present in bronchiolar epithelial cellsin vivoin rats and
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