LONG‐TERM SURVIVAL IN SMALL CELL LUNG CARCINOMA
作者:
R. N. HITCHINS,
J. PHILLIPS,
R. L. WOODS,
期刊:
Australian and New Zealand Journal of Medicine
(WILEY Available online 1988)
卷期:
Volume 18,
issue 1
页码: 3-7
ISSN:0004-8291
年代: 1988
DOI:10.1111/j.1445-5994.1988.tb02231.x
出版商: Blackwell Publishing Ltd
关键词: Small cell lung carcinoma;combined modality therapy;long‐term survival
数据来源: WILEY
摘要:
Abstract:We assessed outcome in 208 patients with small cell lung carcinoma two to seven years after treatment with combination chemotherapy, with or without chest and cranial radiotherapy. Fourteen patients (6.7%) survived cancer free for 30 months or longer. Nine of these (64%) had limited disease at diagnosis and four others had extensive disease with only one metastatic site. Two patients remain alive and disease free more than five years after diagnosis but median survival is still only 3.2 years. One patient died from intercurrent causes at 5.4 years but was free from small cell lung carcinoma at autopsy. Six patients are alive and disease free at intervals greater than 30 months but less than five years from diagnosis. All surviving patients are fully active with lifestyles similar to that prior to diagnosis. Five patients died from small cell lung carcinoma which relapsed more than 30 months after diagnosis. A few patients with small cell lung carcinoma are cured but 30‐month survival is insufficient to show cure as late relapses do occur. Late toxicity from aggressive therapy does not appear to outweigh the benefits of long‐term survival and potential cure in small cell lung carcin
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