In vivoCharacteristics of Temperature-Sensitive Host Range Mutants of Herpes Simplex Virus Type 2
作者:
Roger W. Koment,
Fred Rapp,
期刊:
Intervirology
(Karger Available online 1975)
卷期:
Volume 5,
issue 1-2
页码: 10-20
ISSN:0300-5526
年代: 1975
DOI:10.1159/000149876
出版商: S. Karger AG
关键词: Herpes simplex virus;Host range mutants;Temperature-sensitive mutants;In vivostudies
数据来源: Karger
摘要:
The in vivo properties of four host range temperature-sensitive (ts) mutants of herpes simplex virus type 2 (HSV-2) were correlated with known in vitro characteristics. Mutants and parental virus were inoculated into newborn and weanling mice and weanling hamsters by intracranial and subcutaneous routes, and into weanling rabbits by corneal scarification. In all cases the pattern of attenuation of mutants in vivo correlated with their stability in vitro at 39°. The most attenuated mutant (mutant 69) was also the most consistent in its inability to induce cytopathic effects (CPE) in vitro or to replicate under nonpermissive conditions. Conversely, the most virulent mutant (mutant 41) was the least stable under nonpermissive conditions
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