Chemoprevention: Insights into biological mechanisms and promising food factors
作者:
Akira Murakami,
Hajime Ohigashi,
Koichi Koshimizu,
期刊:
Food Reviews International
(Taylor Available online 1999)
卷期:
Volume 15,
issue 3
页码: 335-395
ISSN:8755-9129
年代: 1999
DOI:10.1080/87559129909541194
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Chemoprevention with food phytochemical is currently regarded as one of the noticeable scientific fields. A large body of data from epidemio‐logic and rodent studies has demonstrated that ingestion of vegetables and fruits is occasionally beneficial for reduction of cancer risks in humans. Recent clinical trials using ubiquitous antioxidants such as α‐carotene, however, have yet to show their cancer preventive effect despite the fact that they have been reported to be chemopreventive agents in rodent models. One of the goals of this review is to address useful and reliable methodology to detect promising chemopreventive agents from edible plants by highlighting molecular mechanisms of multistage carcinogenesis.
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