Pathogenic micro‐organisms isolated from West African grasshoppers (Acrididae) included entomopoxviruses, protozoa, fungi, and a rickettsia. Entomopoxviruses were isolated fromCataloipus fuscocoerulipes(Krauss),C. cymbiferus(Krauss),Oedaleus senegalensis(Krauss),O. nigeriensisUvarov,Krassaria angulifera(Krauss) andHeteracris annulosus(Walker). Two species of microsporidia (Protozoa) were isolated fromAcorypha glaucopsis(Walker),K. angulifera, O. senegalensis, O. nigeriensis, Hieroglyphus daganensisKrauss andAcrida bicolor(Thunberg). The amoebic protozoanMalameba locustae(King & Taylor) was observed inO. senegalensisandDiabolocatantops axillaris(Thunberg). A yeast‐type fungus, observed inO. senegalensisand an undeterminedAnacridiumsp., was isolated fromAiolopus thalassinus(Fab.), A rickettsia was isolated fromZonocerus variegatus(L.).