首页   按字顺浏览 期刊浏览 卷期浏览 Altered Expression of NGF and P75 NGF-receptor by Fibroblasts of Injured Teeth Precedes...
Altered Expression of NGF and P75 NGF-receptor by Fibroblasts of Injured Teeth Precedes Sensory Nerve Sprouting

 

作者: ByersMargaret R.,   WheelerEsther F.,   BothwellMark,  

 

期刊: Growth Factors  (Taylor Available online 1992)
卷期: Volume 6, issue 1  

页码: 41-52

 

ISSN:0897-7194

 

年代: 1992

 

DOI:10.3109/08977199209008870

 

出版商: Taylor&Francis

 

关键词: nerve growth factor;dental pulp;mesenchymal cells;trigeminal denervation;dexamethasone;adult rats

 

数据来源: Taylor

 

摘要:

AbstractProfuse sprouting of sensory nerve fibers occurs in tooth pulp by 1-4 days following dentin injury. A possible role for nerve growth factor (NGF) in that neural response is suggested here by the demonstration that NGF mRNA and protein are increased 6 hr after injury to adult rat molars. The enhanced expression of NGF mRNA was localized to fibroblasts underlying the injury. A concomitant depletion of mRNA encoding the 75 Kd NGF receptor (NGFR) was observed in those fibroblasts. The increase in NGF mRNA was transitory and mRNA levels fell below normal levels by 2 days after injury. Both NGF and NGFR mRNA remained low thereafter in injured pulp. The inverse shifts in fibroblastic mRNA encoding NGF and NGFR were not affected by prior denervation of the tissue, or by pretreatment with dexamethasone. The regulatory mechanisms therefore must involve endogenous, non-neuronal, non-inflammatory factors that are released in response to injury.

 

点击下载:  PDF (1737KB)



返 回