Altered Expression of NGF and P75 NGF-receptor by Fibroblasts of Injured Teeth Precedes Sensory Nerve Sprouting
作者:
ByersMargaret R.,
WheelerEsther F.,
BothwellMark,
期刊:
Growth Factors
(Taylor Available online 1992)
卷期:
Volume 6,
issue 1
页码: 41-52
ISSN:0897-7194
年代: 1992
DOI:10.3109/08977199209008870
出版商: Taylor&Francis
关键词: nerve growth factor;dental pulp;mesenchymal cells;trigeminal denervation;dexamethasone;adult rats
数据来源: Taylor
摘要:
AbstractProfuse sprouting of sensory nerve fibers occurs in tooth pulp by 1-4 days following dentin injury. A possible role for nerve growth factor (NGF) in that neural response is suggested here by the demonstration that NGF mRNA and protein are increased 6 hr after injury to adult rat molars. The enhanced expression of NGF mRNA was localized to fibroblasts underlying the injury. A concomitant depletion of mRNA encoding the 75 Kd NGF receptor (NGFR) was observed in those fibroblasts. The increase in NGF mRNA was transitory and mRNA levels fell below normal levels by 2 days after injury. Both NGF and NGFR mRNA remained low thereafter in injured pulp. The inverse shifts in fibroblastic mRNA encoding NGF and NGFR were not affected by prior denervation of the tissue, or by pretreatment with dexamethasone. The regulatory mechanisms therefore must involve endogenous, non-neuronal, non-inflammatory factors that are released in response to injury.
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