Changes in Hematologic Parameters Among Japanese HTLV‐I Carriers
作者:
Seth Welles,
Nobuyoshi Tachibana,
E. Orav,
Akihiko Okayama,
Junzo Ishizaki,
Nancy Mueller,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 1
页码: 92-97
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: HTLV-I;Adult T-cell leukemia;Abnormal lymphocytes;White blood cell differentials;Red blood cells;Serum albumin.
数据来源: OVID
摘要:
SummaryHematologic data from 1,039 persons who participated in the Miyazaki Cohort study on human T-cell lymphotropic virus type-I (HTLV-I) infection were analyzed. Individuals were classified by HTLV-I antibody status and the presence of abnormal lymphocytes (Ably). We identified several differences in selected leukocyte populations: lymphocyte percent was higher among the HTLV-I carriers with Ably (36.5 ± 2.0%, n = 29) compared with the carriers without Ably (33.1 ± 0.6%, n = 299) and the seronegatives (34.6 ± 0.4%, n = 711) (p= 0.04). Conversely, there was a trend of decreasing eosinophil percent among both carrier groups with the lowest percent among carriers with Ably (1.8 ± 0.5%) compared with the seronegatives (2.8 ± 0.1%) (p = 0.05). Mean basophil percent w, decreased among both carriers groups (p = 0.09). Additionally, red cell count was elevated among the carriers with Ably (461 ±7 x 104/mm3) compared with the seronegatives (446 ± 2 x 104/mm3) (p = 0.03). The HTLV-I carriers with Ably had lower serum albumin (4.39 ± 0.05 g%) compared with the seronegatives (4.47 ± 0.01 g%) (p = 0.10). These alterations may be a consequence of HTLV-I infection, with the greatest changes among carriers with Ably, a subset thought to be at risk for developing adult T-cell leukemia.
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