Effect of glycyrrhizin on lysis of hepatocyte membranes induced by anti‐liver cell membrane antibody
作者:
YASUKO SHIKI,
KOHJI SHIRAI,
YASUSHI SAITO,
SHO YOSHIDA,
YOSHIO MORI,
MASAFUMI WAKASHIN,
期刊:
Journal of Gastroenterology and Hepatology
(WILEY Available online 1992)
卷期:
Volume 7,
issue 1
页码: 12-16
ISSN:0815-9319
年代: 1992
DOI:10.1111/j.1440-1746.1992.tb00927.x
出版商: Blackwell Publishing Ltd
关键词: antibody;glycyrrhizin;hepatocyte membranes;lysis.
数据来源: WILEY
摘要:
ABSTRACTStudies were made on why glycyrrhizin injection decreases the plasma aspartate aminotransferase (AST) and alanine aminotransferase activities in patients with chronic hepatitis.1For this, rat hepatocytes were isolated, and incubated with antibody raised against rat liver cell membranes, and the effect of glycyrrhizin on their release of transaminase was investigated. Isolated rat hepatocytes released AST on incubation with anti‐liver cell antibody in the presence of complement. At this time, their endogenous phospholipase A2activity was increased. Cultured hepatocytes also released the transaminase in the presence of venom phospholipase A2. Glycyrrhizin suppressed the release of transaminase in the presence of either anti‐liver cell membrane antibody or phospholipase A2. These results suggest that antibody treatment raised the phospholipase A2activity in liver cell membranes, resulting in release of transaminases, and that glycyrrhizin suppressed this increase in phospholipase A2activity and so inhibited the release of transamin
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