The effects of itravitreally injected endothelin-1 on the iris-ciliary body microvasculature in rabbits
作者:
SugiyamaKazuhisa,
HaqueMohammad Sabbir Reza,
OndaEiji,
TaniguchiToru,
KitazawaYoshiaki,
期刊:
Current Eye Research
(Taylor Available online 1996)
卷期:
Volume 15,
issue 6
页码: 633-637
ISSN:0271-3683
年代: 1996
DOI:10.3109/02713689609008903
出版商: Taylor&Francis
关键词: endothelin;iris vasculature;ciliary body;vascula-ture;vascular casting;rabbit
数据来源: Taylor
摘要:
Purpose. We previously reported that intravitreal injection of 0.5μg of endothelin-1 (ET-1) caused both a sustained reduction of intraocular pressure (IOP) and decreased aqueous production in the rabbit eye. On the theory that these effects might have resulted from a sustained reduction of blood flow to the ciliary body due to ET-1-mediated vasoconstriction, in the present study we attempted to determine if ET-1 causes any changes in the vascular caliber of the iris-ciliary body.Methods. ET-1 solution (0.5μ.g) was injected into the vitreous of one eye of each of 10 albino rabbits; the same amount of vehicle was injected into the contralateral eyes. One h following these injections in five of the rabbits and 24 h following them in the other five rabbits, ocular microvascular castings were obtained under controlled physiologic conditions, and the amount of vasoconstriction of the arterioles branching from the major arterial circle of the iris (MAC) and supplying the iris-ciliary body was measured by a scanning electron microscope and expressed as a percentage.Results. The ET-1 caused a statistically significant focal vasoconstriction in the treated eyes as compared with the contralateral, control eyes (9.9% at 1 h and 6.2% at 24 h; both P =. 0001).Conclusions. Intravitreally injected ET-1 caused statistically significant, but only mild vasoconstriction of the arterioles supplying the ciliary processes.
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