Simultaneuus Spectrophotometric Deermination of Phenazo-Pyridine and Nitrofurantoin in Tablets
作者:
S.M. Hassan,
F. Belal,
M.K. Sharaf El-Din,
M. Sultan,
期刊:
Analytical Letters
(Taylor Available online 1988)
卷期:
Volume 21,
issue 7
页码: 1199-1210
ISSN:0003-2719
年代: 1988
DOI:10.1080/00032718808055507
出版商: Taylor & Francis Group
关键词: Phenazopyridine;Nitrofurantoin;Spectruphotomtric Procedure
数据来源: Taylor
摘要:
Two spectrophotometric methods are proposed for the simultaneous spectrophotometric determination of phenaaopyridine and nitrofurantoin in tablets. No preliminary separation step is required. The first method involves the use of the modified Vierardt equation as developed by Glenn. The second method is based on the spectral changes induced bg reduction using Zn/HCl; the absorption spectrum of nitrofurantoin completely disappears, Phenazopyridine on the other hand develops a new absorption spectra at 320 nm, the absorbance ratio of the peak at 380 nm to that at 320 nm could be adopted to develop a spectrophotometric method for the determination of both compounds in admixture. The suggested methods were applied to the determination of the two compounds in tablets, and the results obtained were accurate and precise.
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