Renal cyclic 3′,5′‐guanosine monophosphate and sodium excretion in Dahl salt‐resistant and Dahl salt‐sensitive ratscomparison of the roles of bradykinin and nitric oxide
作者:
Lesley Millatt,
Helmy Siragy,
期刊:
Journal of Hypertension
(OVID Available online 2000)
卷期:
Volume 18,
issue 10
页码: 1491-1496
ISSN:0263-6352
年代: 2000
出版商: OVID
关键词: kidney;Dahl rat;cGMP;bradykinin;nitric oxide;icatibant;L-NAME;hypertension;sodium;microdialysis
数据来源: OVID
摘要:
ObjectiveThe purpose of this study was to determine the relative importance of bradykinin and nitric oxide (NO) in mediating renal responses to altered sodium intake in Dahl salt-resistant (Dahl-SR) and salt-sensitive (Dahl-SS) rats.Design and methodsDahl-SR and Dahl-SS rats consumed a diet containing 0.15% (low) or 4.0% (high) sodium chloride for 10 days. A microdialysis technique was then used to measure renal cortical interstitial fluid (RIF) cyclic 39,59-guanosine monophosphate (cGMP) production in anesthetized rats, under baseline conditions and during acute cortical infusion of either the bradykinin B2 receptor antagonist icatibant or the NO synthase inhibitor nitro-L-arginine methyl ester (L-NAME). Urine sodium excretion was monitored simultaneously by ureter cannulation.ResultsBaseline sodium excretion was similar in the two types of rats, but RIF cGMP was significantly elevated in Dahl-SR compared to Dahl-SS rats on both low and high sodium diets. Icatibant infusion significantly reduced both RIF cGMP and sodium excretion in Dahl-SR rats during low sodium intake, but had no effect in Dahl-SS rats on either diet. L-NAME infusion significantly reduced sodium excretion in Dahl-SR and Dahl-SS rats, during both low and high sodium intake. L-NAME infusion caused a significant reduction in RIF cGMP in Dahl-SR and Dahl-SS rats on low sodium diet, but reduced RIF cGMP only in Dahl-SR rats on high sodium diet.ConclusionThese data suggest a potential role for cortical bradykinin, but not NO, in mediating the differences in the renal response to low sodium intake between Dahl-SR and Dahl-SS rats.
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