Development of Vaccination Strategies that Elicit Broadly Neutralizing Antibodies against Human Immunodeficiency Virus Type 1 in Both the Mucosal and Systemic Immune Compartments
作者:
David Hone,
Anthony DeVico,
Timothy Fouts,
David Onyabe,
Simon Agwale,
Charles Wambebe,
William Blattner,
Robert Gallo,
George Lewis,
期刊:
Journal of Human Virology
(OVID Available online 2002)
卷期:
Volume 5,
issue 1
页码: 17-23
ISSN:1090-9508
年代: 2002
出版商: OVID
关键词: Immunodeficiency virus;neutralizing antibody;vaccine;mucosal immunity;adjuvant
数据来源: OVID
摘要:
The antigenic diversity, rapid genetic integration into host cell DNA, and immune evasion tactics of human immunodeficiency virus type 1 (HIV-1) create formidable obstacles to the development of an effective vaccine against it. In spite of this, the advent of conformationally constrained HIV-1 Env and gp120 immunogens has made it feasible to formulate HIV-1 vaccines that induce broadly cross-reactive neutralizing antibodies and afford protection through humoral mechanisms. This paper reviews recent advances made by the authors toward the development of an HIV-1 vaccine that elicits such antibodies in both the mucosal and systemic immune compartments.
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