Electron microscopy of the complement protein C1q from the bullfrog,Rana catesbeiana
作者:
Henry S. Slayter,
Richard J. Alexander,
Lisa A. Steiner,
期刊:
European Journal of Immunology
(WILEY Available online 1983)
卷期:
Volume 13,
issue 2
页码: 102-106
ISSN:0014-2980
年代: 1983
DOI:10.1002/eji.1830130204
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractThe complement protein C1q, isolated from bullfrog (Rana catesbeiana) serum, was found by electron microscopy to resemble human C1q; peripheral globular units, probably six in number, are connected by thin strands to a hollow stem‐like central structure. The dimensions of frog and human C1q were also found to be very similar. These results are consistent with earlier observations that frog and human C1q are similar, although not identical, in overall size, subunit structure, amino acid composition, and functional properties. Evidently this protein, which binds to antigen‐antibody complexes and to C1r and C1s, thereby forming a physical link between the immune and complement systems, has been highly conserved in evolut
点击下载:
PDF
(634KB)
返 回