TS+OCD‐like neuropotentiated mice are supersensitive to seizure induction
作者:
Keith Campbell,
Matthew Veldman,
Michael McGrath,
Frank Burton,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 10
页码: 2335-2338
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Amygdala;Cholera toxin;Compulsions;D1 receptor;Epilepsy;Glutamate;Insular;Piriform;Somatosensory;Tics
数据来源: OVID
摘要:
Seizures can be induced by systemic dopamine D1 receptor agonists or by cortical-limbic neurostimulation non-selectively. Seizures are also often associated with tics and compulsions, which likewise involve cortical-limbic hyperactivity. To determine if selective potentiation of cortical-limbic D1 receptor-expressing (D1+) neurons increases seizure susceptibility, we administered pentylenetetrazole (PTZ) to mice that express a neuropotentiating transgene only in a glutamatergic, corticallimbic subset of D1+ neurons (D1CT-7 line). These mice exhibited increased PTZ-dependent seizure incidence, onset rate and intensity. Because D1CT-7 mice also exhibit tic+compulsion-like behaviors, this implies that glutamatergic hyperactivity induced by cortical-limbic D1+ neuropotentiation facilitates not only epilepsy but also tics and compulsions. This suggests a dopamine-regulated glutamatergic basis for all three states and may explain why they often co-exist in humans.
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