Sympathetic axons surround neuropeptide‐negative axotomized sensory neurons
作者:
Matt Ramer,
Mark Bisby,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 13
页码: 3109-3113
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Calcitonin gene-related peptide;Dorsal root ganglion;Galanin;Neuropathic pain;Neuropeptide Y;Substance P;Tyrosine hydroxylase;Vasoactive intestinal polypeptide
数据来源: OVID
摘要:
NERVE injury can lead to sympathetically dependent neuropathic pain. A possible site of sympathetic—sensory interaction is the dorsal root ganglion (DRG), where sympathetic axons form pericellular ‘baskets’ around a subpopulation of DRG neurons. Since these structures possibly represent functional units of sympathetic pain, we attempted to characterize the neuropeptidergic phenotype of basketed DRG neurons. We performed double-labeling immunohistochemistry for tyrosine hydroxylase and neuropeptides on DRG sections, 2 weeks following L5 spinal nerve ligation (a well-characterized animal model of sympathetic pain). We found that basketed DRG neurons typically do not contain substance P, calcitonin gene-related peptide, galanin, neuropeptide tyrosine, or vasoactive intestinal polypep-tide, and we conclude that if sympathetic baskets contribute to neuropathic pain, the involvement of these neuropeptides is unimportant.
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