首页   按字顺浏览 期刊浏览 卷期浏览 Preparation of 5‐substituted benzylbarburituric acids and investigation of the effect o...
Preparation of 5‐substituted benzylbarburituric acids and investigation of the effect of the benzyl and substituted benzyl groups on the acidity of barbituric acid

 

作者: John V. Tate,   William N. Tinnerman,   Vito Jurevics,   Harold Jeskey,   Edward R. Biehl,  

 

期刊: Journal of Heterocyclic Chemistry  （WILEY Available online 1986）
卷期: Volume 23, issue 1  

页码: 9-11

 

ISSN:0022-152X

 

年代: 1986

 

DOI:10.1002/jhet.5570230103

 

出版商: Wiley‐Blackwell

 

数据来源: WILEY

 

摘要:

AbstractThe acidity of 5‐benzylbarbituric acid and a series of 5‐substituted benzylbarbituric acids has been determined in 50% ethanol/water and they were found to be more acidic than barbituric acid. The pKas of these derivatives obey Hammett's equation indicating that their acidity is affected by substituents in the same manner as the benzoic acid ionization constants. A synthesis of these acids is descri

 

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