THE EFFECT OF HYPERTENSION AND ACE INHIBITION ON ARTERIAL STRUCTURE AND COMPLIANCE
作者:
M. E. Safar,
B. I. Levy,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1992)
卷期:
Volume 19,
issue S19
页码: 29-32
ISSN:0305-1870
年代: 1992
DOI:10.1111/j.1440-1681.1992.tb02807.x
出版商: Blackwell Publishing Ltd
关键词: angiotensin‐converting enzyme inhibition;hypertension;large arteries
数据来源: WILEY
摘要:
SUMMARY1. Large artery dilatation may be produced by angiotensin‐converting enzyme inhibition in hypertensive subjects independently of blood pressure reduction. The resulting increase in arterial compliance may be due to both blood pressure reduction and to arterial smooth muscle relaxation.2. In healthy volunteers and in hypertensive subjects, dosages producing large artery dilatation seem to be even higher than those causing arteriole dilatation with the resulting blood pressure reduction.3. It may be important to consider such findings for the remodelling of the cardiovascular system produced by angiotensin‐converting enzyme inhibit
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