Epidermodysplasia Verruciformis as a Model of Human Papillomavirus‐Induced Genetic CancersThe Role of Local Immunosurveillance
作者:
SLAVOMIR MAJEWSKI,
STEFANIA JABLONSKA,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1992)
卷期:
Volume 304,
issue 3
页码: 174-179
ISSN:0002-9629
年代: 1992
出版商: OVID
关键词: Cutaneous cancer;Epidermodysplasia verruciformis;Immunogenetics;Oncogenic papillomaviruses.
数据来源: OVID
摘要:
Epidermodysplasia verruciformis (EV) presents a genetically determined, unusual susceptibility to infection with EV-specific human papillomaviruses (HPVs) related to abrogation of immunosurveillance exclusively against these viruses. The cutaneous viral carcinogenesis depends upon potentially oncogenic HPVs, the cocarcinogenic effect of ultraviolet irradiation, and genetic host factors, presumably a defect of anti-oncogenes or alleles of major bistocompatibility complex and tumor necrosis factor locus involved in antigen presentation.
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