首页   按字顺浏览 期刊浏览 卷期浏览 Subacute (4‐week) inhalation toxicity study of formaldehyde in male rats: 8‐hour interm...
Subacute (4‐week) inhalation toxicity study of formaldehyde in male rats: 8‐hour intermittentversus8‐hour continuous exposures

 

作者: J. W. G. M. Wilmer,   R. A. Woutersen,   L. M. Appelman,   W. R. Leeman,   V. J. Feron,  

 

期刊: Journal of Applied Toxicology  （WILEY Available online 1987）
卷期: Volume 7, issue 1  

页码: 15-16

 

ISSN:0260-437X

 

年代: 1987

 

DOI:10.1002/jat.2550070104

 

出版商: John Wiley&Sons, Ltd.

 

关键词: formaldehyde;inhalation;rats;intermittent versus continuous exposure

 

数据来源: WILEY

 

摘要:

AbstractMale Wistar rats were exposed for 4 weeks, 5 days a week, to 0 (controls), 5 or 10 ppm formaldehyde continuously (8 hours a day), or to 10 or 20 ppm formaldehyde interruptedly (eight 30 min exposure periods separated by 30 min non‐exposure periods). Histopathology and cell proliferation studies indicated that under the conditions of exposure used, concentration rather than the total dose of formaldehyde determined the severity of the cytotoxic effects on the nasal epitheliu

 

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