Tyrosinase Inhibitory and Anti-Tumor Promoting Activities of Compounds Isolated from Safflower (Carthamus Tinctorius L.) and Cotton (Gossypium Hirsutum L.) Oil Cakes
作者:
Akito Nagatsu,
Hui Zhang,
Hajime Mizukami,
Harumi Okuyama,
Jinsaku Sakakibara,
Harukuni Tokuda,
Hoyoku Nishino,
期刊:
Natural Product Letters
(Taylor Available online 2000)
卷期:
Volume 14,
issue 3
页码: 153-158
ISSN:1057-5634
年代: 2000
DOI:10.1080/10575630008041225
出版商: Taylor & Francis Group
关键词: Safflower oil cake;cotton oil cake;antioxidant;tyrosinase inhibitor;anti-tumor-promoter.
数据来源: Taylor
摘要:
Tyrosinase inhibitory and anti-tumor promoting activities of 14 compounds isolated from safflower and cotton oil cakes were evaluated together with the two genins of glycosides, trachorogenin (8a) and quercetin (12a). Catechin (11) and quercetin (12a) showed moderate tyrosinase inhibitory activity.N-(p-Coumaroyl)serotonin (1) and its 5-O-glucoside (3) exhibited weak anti-tyrosinase activity, but potent inhibitory activity on melanine production in the assay. Serotonin derivatives (1-4). 2-hydroxyarctiin (8), matairesinol glycoside (9) and sesquiterpene glucosides (13, 14) exhibited potent inhibitory activity on phorbol-12-myristate-13-acetate induced Epstein-Barr virus early antigen activation, which is the short termin vitroassay for anti-tumor-promoting activity.
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