Determination of Some Cephalosporins Using Derivative Spectrophotometry
作者:
FawzyA. El-yazbi,
MagdaH. Barary,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 5
页码: 629-640
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508066162
出版商: Taylor & Francis Group
关键词: cephalexin;cephalothin sodium;cephradin;degradation;first derivative spectrometry;second derivative spectrometry.
数据来源: Taylor
摘要:
A rapid and simple method for the determination of cephalexin, cephalothin sodium and cephradin without prior separation from their alkali-induced degradation products is presented. By measuring the values of the first and second derivative spectra at certain wavelengths, the concentration of the intact drug can be calculated directly without interference of degradation products. The method was proved using synthetic mixtures of the intact drugs with their degradation products, and its suitability to monitor the stability of the drugs was demonstrated.
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