Coexistence of Tyrosine Hydroxylase and Growth Hormone-Releasing Factor in a Subpopulation of Tubero-Infundibular Neurons of the Rat
作者:
Björn Meister,
Tomas Hökfelt,
Wylie W. Vale,
Paul E. Sawchenko,
Larry Swanson,
Menek Goldstein,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 3
页码: 237-247
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124446
出版商: S. Karger AG
关键词: Dopamine;Growth hormone-releasing factor;Coexistence;Corelease;Growth hormone;Secretion;control of
数据来源: Karger
摘要:
The distribution of growth hormone-releasing factor (GRF) and tyrosine hydroxylase (TH), a marker for dopamine neurons in this region, was analyzed in the mediobasal hypothalamus with indirect immunofluorescence histochemistry and an elution-restaining procedure. TH-like immunoreactivity was present in most GRF-immunoreactive cells in the ventral part of the arcuate nucleus (ventral A12 dopamine cell group). Dopamine cells in the dorsal A12 group and, for example, in the hypothalamic A14 cell group seemed to lack GRF peptide. Partly overlapping GRF- and TH-immunoreactive fibers in the median eminence were observed, indicating possible coexistence of the two compounds also in nerve endings close to portal vessels. These findings suggest that a subpopulation of A12 dopamine neurons produces, stores and releases a GRF-like peptide. Possible interactions of GRF and dopamine in the control of growth hormone secretion are discussed.
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