Variations in cone populations for red–green color vision examined by analysis of mRNA
作者:
Stephanie Hagstrom,
Jay Neitz,
Maureen Neitz,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 1963-1967
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Color vision;Cone;Opsin;Photoreceptor;Retina
数据来源: OVID
摘要:
IN the central human retina, there are estimated to be nearly two L cone photoreceptors for each M cone. The extent to which this value varies across individuals is unclear and little is known about how the M:L cone ratio might change with retinal location. To address these questions, the ratio of M:L cone pigment mRNA was examined at different locations. For patches of central retina, the average M:L ratio was about 2:3 which decreased to about 1:3 for patches 40°eccentric. There were also large individual differences among the 23 eyes examined. The extremes differed in central M:L mRNA ratio by a factor of > 3. The measured differences in mRNA ratio are proposed to reflect differences in photo-receptor ratio. Such variations provide unique opportunities for understanding how the neural circuitry for color vision is affected by changes in cone ratio.
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