Cardiovascular effects of intermittent drinking: assessment of a novel animal model of human alcoholism
作者:
David Crandall,
Gregory Ferraro,
Robert Lozito,
Peter Cervoni,
Luther Clark,
期刊:
Journal of Hypertension
(OVID Available online 1989)
卷期:
Volume 7,
issue 8
页码: 683-687
ISSN:0263-6352
年代: 1989
出版商: OVID
关键词: Alcohol;rat;blood pressure;hypertension;withdrawal
数据来源: OVID
摘要:
The development of a novel model of human alcoholism has involved the presentation of a 30% alcohol solution to Sprague–Dawley rats via a syringe-feeding needle apparatus. With twice daily intermittent drinking, rats consumed an equivalent of 7–8g/kg body weight of alcohol, which represented 25% of total daily caloric intake. Alcohol was absorbed rapidly, as significant circulating concentrations were observed within 15min of gavage, eventually peaking at approximately 200 mg% 1 h later. Hemodynamic recordings in the conscious state after a 10-week drinking program indicated a normotensive blood pressure at peak blood alcohol levels, yet a hypertensive response 24 h after the final drink at a time when blood alcohol was not detected. Alcoholic rats continued to gain weight in parallel with controls fedad libitumthroughout the study, and changes in cardiac size and indices of contractility were not affected by 10 weeks of intermittent drinking. Additionally, no histological evidence of cardiac muscle damage was observed in alcoholic animals. Our animal model closely resembles the clinical situation in terms of the pattern of alcohol consumption, circulating concentrations of alcohol and the percentage of caloric intake in the form of alcohol. The hemodynamic changes observed support the hypothesis that alcoholic hypertension may be a manifestation of withdrawal, as opposed to any direct pressor effect of alcohol itself.
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