ImmunoliposomesA Promising Approach to Targeting Cancer Therapy
作者:
Gerd Bendas,
期刊:
BioDrugs
(ADIS Available online 2001)
卷期:
Volume 15,
issue 4
页码: 215-224
ISSN:1173-8804
年代: 2001
出版商: ADIS
关键词: Cancer, treatment;Immunotherapies, therapeutic use;Liposome encapsulation
数据来源: ADIS
摘要:
Immunoliposomes (antibody-coupled liposomes) have been regarded as very attractive drug-targeting systems for chemotherapeutic cancer treatment. Fundamental problems regarding immunoliposome preparation and application such as antibody coupling and immunoliposome stability and pharmacokinetics have been overcome during the last decade. Therefore, several promising studies on tumour targeting have been described in recent years. Adding to existing reviews on liposomal drug delivery, this article focuses on immunoliposome tumour targeting and summarises various experiments of immunoliposome applicationin vitroandin vivowith respect to structural liposomal parameters, therapeutic potential and the requirements of the target sites. New therapeutic trends related to immunoliposomes are also considered. Remaining problems in immunoliposome application, especially immunological aspects, are discussed, as are strategies that might help to overcome these obstacles.
点击下载:
PDF
(132KB)
返 回