Cyclic AMP and adenyl cyclase in the developing rat brain
作者:
M. J. Schmidt,
E. C. Palmer,
W.‐D. Dettbarn,
G. A. Robison,
期刊:
Developmental Psychobiology
(WILEY Available online 1970)
卷期:
Volume 3,
issue 1
页码: 53-67
ISSN:0012-1630
年代: 1970
DOI:10.1002/dev.420030108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: adenyl cyclase;developing rat brain;norepinephrine;cyclic AMP;fluoride effect;phosphodiesterase;rat
数据来源: WILEY
摘要:
AbstractThe level of endogenous cyclic AMP in the rat brainin vivobegan to increase markedly between the third and sixth days after birth, as did the ability of norepinephrine to stimulate the formation of cyclic AMP in brain tissuein vitro.Adenyl cyclase activity in broken cell preparations, when measure in the absence of sodium fluoride, increased with age up to a point, but began to decline between the fifth and ninth days postpartum. Activity continued to increase when measured in the presence of fluoride, suggesting that the apparent stimulatory effect of this ion may in fact be the reversal of an inhibitory influence which is absent or almost absent at birth. Cyclase activity at all ages was restricted to particulate matter, whereas apparent phosphodiesterase activity was present in particulate as well as soluble fractions. The catabolic system for cyclic AMP developed in a similar manner in both fractions. Theophylline produced the same degree of inhibition of this system at all ages.
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