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Pathobiology of focal sclerosis

 

作者: Albert,   Wolthuis Harry,   van Goor Jan,   Weening Joris,  

 

期刊: Current Opinion in Nephrology and Hypertension  （OVID Available online 1993）
卷期: Volume 2, issue 3  

页码: 458-464

 

ISSN:1062-4821

 

年代: 1993

 

出版商: OVID

 

关键词: ICAM-1—intercellular adhesion molecule-1;LDL—low-density lipoprotein;PDGF—platelet-derived growth factor;TGF-β—transforming growth factor-β;TNF-α—tumor necrosis factor-α

 

数据来源: OVID

 

摘要:

This paper briefly reviews recent experimental data derived from work in animals and cell cultures that have increased our understanding of the pathobiologic pathways leading to focal sclerosis. These pathways include glomerular visceral epithelial cell damage, leukocyte infiltration, hyperplasia and matrix accumulation in the mesangium, and endothelial injury.

 

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