Complexing Properties of Amide Oxime of Picolinic Acid (APA) I. Investigation of the APA-99Tc Reaction and of the Biological Distribution of99mTc-APA Complex
作者:
M. Ogiński,
S. Zommer-Urbańska,
J. Joachimiak,
B. Koninrek,
期刊:
Isotopenpraxis Isotopes in Environmental and Health Studies
(Taylor Available online 1983)
卷期:
Volume 19,
issue 12
页码: 431-434
ISSN:0021-1915
年代: 1983
DOI:10.1080/10256018308544956
出版商: Taylor & Francis Group
关键词: Ehrlich ascites tumor;labelling;nuclear medicine;renography;scintiscanning;technetium 99m;technetium complexes
数据来源: Taylor
摘要:
As a result of APA labelling with99mTc reduced by SnCl2at pH 1.9 about 90% of99mTc-APA complex was obtained. Experiments in vivo were carried out on 10 Swiss mice who had Ehrlich tumor inplanted. After 8 days the99mTc-APA complex was administered i. p. – The ADF ratio tumor blood was 2,5. Renoscintigraphy showed that the decline of renal activity, in the stage when excretion prevailed (phase III), was slow and of cumulative nature. Simple synthesis, labelling and low toxity of APA are the factors that advocate further experiments in searching its utility in diagnostics.
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