首页   按字顺浏览 期刊浏览 卷期浏览 Complexing Properties of Amide Oxime of Picolinic Acid (APA) I. Investigation of the AP...
Complexing Properties of Amide Oxime of Picolinic Acid (APA) I. Investigation of the APA-99Tc Reaction and of the Biological Distribution of99mTc-APA Complex

 

作者: M. Ogiński,   S. Zommer-Urbańska,   J. Joachimiak,   B. Koninrek,  

 

期刊: Isotopenpraxis Isotopes in Environmental and Health Studies  (Taylor Available online 1983)
卷期: Volume 19, issue 12  

页码: 431-434

 

ISSN:0021-1915

 

年代: 1983

 

DOI:10.1080/10256018308544956

 

出版商: Taylor & Francis Group

 

关键词: Ehrlich ascites tumor;labelling;nuclear medicine;renography;scintiscanning;technetium 99m;technetium complexes

 

数据来源: Taylor

 

摘要:

As a result of APA labelling with99mTc reduced by SnCl2at pH 1.9 about 90% of99mTc-APA complex was obtained. Experiments in vivo were carried out on 10 Swiss mice who had Ehrlich tumor inplanted. After 8 days the99mTc-APA complex was administered i. p. – The ADF ratio tumor blood was 2,5. Renoscintigraphy showed that the decline of renal activity, in the stage when excretion prevailed (phase III), was slow and of cumulative nature. Simple synthesis, labelling and low toxity of APA are the factors that advocate further experiments in searching its utility in diagnostics.

 

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