Twenty-nine patients with necrotizing fasciitis who were treated with 5% mafenide acetate solution (MAS) as an adjunct after grafting were compared with 45 patients treated without MAS. Statistical analysis of differences was obtained throughPvalues by &khgr;2testing. The MAS+ (M) and MAS− (C) groups were similar in percent skin deficit (M = 7.5%; C = 9.8%), with the extremity being the most common area of infection.Streptococcuswas the most common single organism but polymicrobial infections were the most prevalent (M = 48%; C = 58%). Patients with necrotizing fasciitis treated with MAS had fewer debridements per patient (M = 3.7; C = 5.4), fewer closure procedures (average per patient: M = 1.2; C = 1.73) and a higher percent of first-time closures (83 vs 59%; &khgr;2= 4.26;P= 0.039). There is a trend toward a lower mortality rate (3.4 vs 13%; &khgr;2= 2.00;P= 0.158). We conclude that MAS is a useful adjunct in necrotizing fasciitis wound care protocols.