Lugaro cells target basket and stellate cells in the cerebellar cortex
作者:
Jeanne Lainé,
Herbert Axelrad,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2399-2403
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Basket cell;Cerebellar cortex;Cerebellum;GABA;Golgi gold-toning electron microscopy;Golgi staining;Inhibitory interneuron;Lugaro cell;Stellate cell
数据来源: OVID
摘要:
LUGARO cells are fusiform neurons located just beneath the Purkinje cell layer. Their axon projects profusely in the molecular layer and emits some collaterals in the granular layer. We have analysed the molecular layer postsynaptic targets of a Golgi-impregnated Lugaro cell, using the electronmicroscopic gold-toning procedure and post-embedding anti-GABA immunocytochemistry. All the gold-labeled neuritic and somatic profiles were GABA-positive, thus confirming that the Lugaro cell is an inhibitory interneuron. The axonal varicosities of this cell form multiple symmetrical synaptic junctions with basket and stellate cell somata and proximal dendrites, and, perhaps, with the molecular layer dendrites of Golgi interneurons. Lugaro cells thus seem to exert a feed-back inhibiory control on Purkinje cells.
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