Organochlorine Compounds in Relation to Breast Cancer, Endometrial Cancer, and Endometriosis: An Assessment of the Biological and Epidemiological Evidence
作者:
AhlborgUlf G.,
LipworthLoren,
TitusLinda,
ChengChung,
HanbergAnnika,
BaronJohn,
TrichopoulosDimitrios,
OlovHans,
期刊:
Critical Reviews in Toxicology
(Taylor Available online 1995)
卷期:
Volume 25,
issue 6
页码: 463-531
ISSN:1040-8444
年代: 1995
DOI:10.3109/10408449509017924
出版商: Taylor&Francis
关键词: chlorinated insecticides;estrogenic effects;PCBs;PCDDs;PCDFs
数据来源: Taylor
摘要:
AbstractThere is an increasing public and scientific concern that certain chlorinated compounds, recognized as environmental pollutants, may cause estrogen-related neoplastic disease in humans. The main hypothesis has been that certain organochlorines, through their estrogenic actions, might cause breast cancer. From experimental studies, bothin vitroandin vivo, there is evidence that certain organochlorine compounds may cause estrogenic effects, whereas others may cause antiestrogenic effects. In limited studies, some of these compounds in high doses have also been shown to increase and reduce the frequency of estrogen-related tumors in animals. The epidemiological findings regarding the association between organochlorines and breast cancer are inconclusive. However, the largest and best designed study has been interpreted as negative with respect to DDT and polychlorinated biphenyls (PCB) in relation to breast cancer. Associations between organochlorine exposure and endometrial cancer or endometriosis have even more limited empirical basis. The hypothesis that human exposure to environmental levels of organochlorines would favor an estrogenic overactivity leading to an increase in estrogen-dependent formation of mammary or endometrial tumors is not supported by the existingin vitro, animal and epidemiological evidence. It can, however, not be conclusively rejected on the basis of available data.
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