IMMUNE RESPONSE IN MICE TO HAPTEN CONJUGATED SEPHAROSE
作者:
Saija Koskimies,
期刊:
Acta Pathologica Microbiologica Scandinavica Section C Immunology
(WILEY Available online 1977)
卷期:
Volume 85C,
issue 1
页码: 33-40
ISSN:0304-1328
年代: 1977
DOI:10.1111/j.1699-0463.1977.tb03608.x
出版商: Blackwell Publishing Ltd
关键词: Immune response;hapten conjugated Sepharose;mice
数据来源: WILEY
摘要:
Mice were injected intraperitoneally with Sepharose 4B beads coupled with hapten NIP, and their anti‐NIP response was studied by counting antibody forming cells and determining serum titers. Mice responded well to doses of 0.7 ml of packed beads but 0.3 and 1.2 doses induced much weaker responses. Anti‐NIP titers in recipients of 0.7 ml of the antigen lasted nearly constant for at least 7 weeks. Both T cell status of the recipient and use of adjuvant had an effect on the response. Antigen without adjuvant induced primarily IgM antibodies in normal mice, but IgM and IgG in nude mice. WhenHemophilus pertussisor polyacrylic acid was used as adjuvant both normal and nude mice produced IgM and IgG antibodies, and normal mice produced in addition IgA antibod
点击下载:
PDF
(534KB)
返 回