Reactivity of Human Keratinocytes with the Antimonocytic Monoclonal Antibody Anti-Leu M2
作者:
H. Niedecken,
H. Biltz,
R. Bauer,
H.W. Kreysel,
期刊:
Dermatology
(Karger Available online 1988)
卷期:
Volume 176,
issue 4
页码: 170-175
ISSN:1018-8665
年代: 1988
DOI:10.1159/000248699
出版商: S. Karger AG
关键词: Keratinocytes;Anti-Leu M2;Immunoperoxidase study
数据来源: Karger
摘要:
Skin biopsies from 49 patients with 21 different dermatoses and biopsies of normal skin were investigated with regard to the reactivity of keratinocytes with the monoclonal antimonocytic antibody anti-Leu M2 using the avidin-biotin-peroxidase complex method. In all excisates, a cytoplasmic reaction of keratinocytes was seen which was regularly weaker in the basal layers of the epidermis than in the upper layers. Marked differences in the labelling intensity were shown between the individual dermatoses. Keratinocytes have now been shown to react with several monoclonal antibodies directed against monocytic antigens; therefore the functional significance of this should be discussed.
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