Teratogenicity of secalonic acid d in mice
作者:
C. S. Reddy,
R. V. Reddy,
A. W. Hayes,
A. Ciegler,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1981)
卷期:
Volume 7,
issue 3-4
页码: 445-455
ISSN:0098-4108
年代: 1981
DOI:10.1080/15287398109529993
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Teratogenicity and fetotoxicity of secalonic acid D, a toxic fungal metabolite produced byPenicillium oxalicum, were investigated with pregnant CD1 mice. The compound was administered ip on d 7–15 of pregnancy. A dose‐dependent reduction in weight gain of mothers receiving all doses of secalonic acid D and an increase in resorptions of implanted embryos of dams treated with more than 5 mg/kg secalonic acid D occurred. The latter effect was nearly 100% at 15 or 9 mg/kg given in NaHCO3with or without dimenthyl sulfoxide (DMSO), respectively. A corresponding decrease in the percent of live fetuses and a decrease in the average fetal body weight on d 19 of pregnancy also occurred. Multiple gross, skeletal, and visceral anomalies were noted in fetuses born to mothers receiving 10 mg/kg or more in NaHCO3containing DMSO. In NaHCO3alone, the minimum teratogenic dose was 6 mg/kg. Major malformations included cleft palate, cleft lip, open eyelids, missing phalangeal ossification centers, and shortened mandibles. The results indicated that secalonic acid D is embryocidal and teratogenic as well as fetotoxic when given to female CD1 mice during pregnancy.
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