Ventilatory and Pulmonary Vascular Responses to Acute Hypoxia Are Nonuniform in Healthy Man
作者:
Tatsuji Naito,
Yoshiyuki Miyahara,
Satoshi Ikeda,
期刊:
Respiration
(Karger Available online 1995)
卷期:
Volume 62,
issue 4
页码: 185-189
ISSN:0025-7931
年代: 1995
DOI:10.1159/000196445
出版商: S. Karger AG
关键词: Vasoconstriction, hypoxic pulmonary;Ventilation, control of;Hypoxia, ventilatory response to;Hypoxia, acute
数据来源: Karger
摘要:
The present study was undertaken to examine the pulmonary vascular and ventilatory responses to acute hypoxia in healthy individuals. Pulmonary hemodynamics and minute ventilation (VE) were serially measured during inhalation of 13% O2 for 15 min. There was a wide variability in the pulmonary vascular response to acute hypoxia, and a significant negative correlation between the initial increase in VE after the start of hypoxia (ΔVE) and the percent increase in mean pulmonary arterial pressure (r = -0.646; p < 0.01). The fall in arterial oxygen tension significantly decreased in response to an increase in ΔVE. These results support the view that a blunted ventilatory response to acute hypoxic stimulation enhances alveolar hypoxia, thereby favoring the constriction of pulmonary vasculature. Thus, our results suggest that the ventilatory response to acute hypoxia plays a significant role in the pulmonary vascular response to acute hypoxi
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