Deuteration with Lindlar's catalyst: Effects of various poisons on isotopic purity
作者:
R. O. Adlof,
E. A. Emken,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1984)
卷期:
Volume 21,
issue 1
页码: 75-79
ISSN:0362-4803
年代: 1984
DOI:10.1002/jlcr.2580210108
出版商: John Wiley&Sons, Ltd.
关键词: Deuteration;Catalyst;Lindlar;Methyl Stearolate
数据来源: WILEY
摘要:
AbstractThe Lindlar‐catalysed deuteration of methyl stearolate was studied to determine the effect of various poisons on the rate of reaction and on the isotopic purity of the methyl oleate‐9, 10‐d2produced. Poisons containing both exchangable and nonexchangable α protons on the heterocyclic ring [quinoline, quinaldine, γ‐collidine, acridine, and pyridine] were used. All poisons yielded methyl oleate‐9, 10‐d2having 94–97% isotopic purity. Very little over‐reduction of oleate to stearate occurred. Lindlar‐catalysed H‐D exchange involving the poison
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