Effect of Canthaxanthin on Chemically Induced Mammary Carcinogenesis
作者:
Clinton J. Grubbs,
Isao Eto,
Margaret Juliana,
Laura M. Whitaker,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 3
页码: 239-245
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226935
出版商: S. Karger AG
关键词: Methylnitrosourea;Dimethylbenzanthracene;Chemoprevention;Mammary cancer;Carotenoids;Canthaxanthin
数据来源: Karger
摘要:
Canthaxanthin, a carotenoid with no vitamin A activity, was evaluated for its efficacy in the prevention of chemically induced mammary cancers. Canthaxanthin was administered in the diet at two dose levels (3,390 or 1,130 mg/kg diet). In the dimethylbenzanthracene-induced mammary cancer model, diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen resulted in a 65% reduction in the number of mammary cancers. The feeding of canthaxanthin after the administration of methylnitrosourea had no significant effect on mammary carcinogenesis. These data demonstrate that canthaxanthin, at least in these models of mammary cancer, is active in preventing cancer initiation and not promotion. Analysis of tissues by high-pressure liquid chromatography revealed that canthaxanthin levels in the liver are very high when compared to those in the mammary gland. The observation that canthaxanthin is highly effective in preventing cancer initiation without toxicity suggests that carotenoids not possessing vitamin A activity should be further evaluated as chemopreventive agents.
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