首页   按字顺浏览 期刊浏览 卷期浏览 Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of...
Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats

 

作者: J. Witkin,   L. Perez,  

 

期刊: Behavioural Pharmacology  (OVID Available online 1990)
卷期: Volume 1, issue 3  

页码: 247-254

 

ISSN:0955-8810

 

年代: 1990

 

出版商: OVID

 

关键词: KeywordsBuspirone;Gepirone;Benzodiazepines;Serotonin antagonists;Dopamine antagonists;Punished behavior;Rats

 

数据来源: OVID

 

摘要:

Lever-press responding of male Sprague-Dawley rats was maintained under a conflict procedure in which every tenth response produced both food and electric shock (punished responding); every thirtieth response produced only food in the presence of a separate stimulus. The benzodiazepines, diazepam and chlordiazepoxide, increased responding 4− to 6-fold. Buspirone and its structural analog, gepirone, only moderately and inconsistently increased responding (1.5− and 2-fold, respectively). The dopamine-2 (D-2) receptor antagonist, sulpiride, but not haloperidol had effects similar to buspirone. The D-l antagonist SCH 23390 was not active. The non-selective serotonin (5HT) antagonists, cyproheptadine and methysergide, consistently increased responding 2-fold, but the 5HT-2 antagonists, ketanserin, pirenperone, ritanserin, R-56 413, and LY 53857 and the 5HT-1A agonist, 8-OH-DPAT, were inactive. In pigeons, serotonergic compounds have been shown to increase punished responding. The present results suggest that exploitation of this species difference may be helpful in evaluating new chemicals for novel anxiolytic activity and for investigation of their mechanisms of action.

 

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