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Pharmacokinetics of Intravenous Cefotaxime in Patients Undergoing Chronic Hemodialysis

 

作者: Joel,   Chodos Elliot,   Francke Martin,   Saltzman Harold,  

 

期刊: Therapeutic Drug Monitoring  (OVID Available online 1981)
卷期: Volume 3, issue 1  

页码: 71-74

 

ISSN:0163-4356

 

年代: 1981

 

出版商: OVID

 

关键词: Pharmacokinetics;Cefotaxime;Hemodialysis;Cephalosporin

 

数据来源: OVID

 

摘要:

The pharmacokinetics of intravenously administered cefotaxime were studied in 11 patients with creatinine clearances of less than 7 ml/min who were undergoing chronic hemodialysis. Eight were studied during dialysis, and 3 were studied between dialyses. Pharmacokinetic parameters were determined using a two-compartment linear model. The serum half-life of cefotaxime off dialysis ranged from 1.48 to 3.78 hr. The half-life during dialysis was 2.52 \pm 0.34 hr. There was a 28% reduction in serum concentration per hour. A dosage schedule for the use of intravenously administered cefotaxime in patients undergoing hemodialysis is presented.

 

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