Pink‐eyed dilution alleles affect negative surface charges of mouse spermatozoa
作者:
D. Coleman Hash,
H. Glenn Wolfe,
期刊:
Developmental Genetics
(WILEY Available online 1979)
卷期:
Volume 1,
issue 1
页码: 61-68
ISSN:0192-253X
年代: 1979
DOI:10.1002/dvg.1020010107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: pink‐eyed dilution locus;spermatozoa;sialic acid residues
数据来源: WILEY
摘要:
AbstractAbnormal spermiogenesis in sterile pink‐eyed dilution mutants results in spermatozoa with bizarre sperm heads. The spermatozoa of normal mice bind colloidal iron hydroxide (CIH) along the length of the tail, yet the spermatozoa of pink‐eyed sterile mice show a great reduction in ability to bind CIH. This implies a loss of negative surface charges. The group(s) responsible for the charges are sensitive to methylation but resistant to neuraminidase treatment, even after deacetylation with alkaline treatment. The membrane components containing the negatively charged groups may be neuraminidase‐resistant forms of ganglio
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