PolymorphicN-acetyltransferase (NAT2) genotyping of Emiratis
作者:
Norman Woolhouse,
M Mansoor Qureshi,
Salim Bastaki,
Mahendra Patel,
Yousef Abdulrazzaq,
Riad Bayoumi,
期刊:
Pharmacogenetics
(OVID Available online 1997)
卷期:
Volume 7,
issue 1
页码: 73-82
ISSN:0960-314X
年代: 1997
出版商: OVID
关键词: pharmacogenetics;N-acetyltransferase;genotype;United Arab Emirates
数据来源: OVID
摘要:
PolymorphicN-acetyltransferase (NAT2) genotypes were determined in 106 unrelated Emiratis by PCR-RFLP analysis to obtain estimates of allele frequencies. Thirteen different genotypes were found, four associated with the rapid acetylator phenotype and nine with the slow acetylator phenotype. Among 67 phenotypically slow acetylators, there was 100% concordance between phenotype and genotype. Among 39 phenotypically rapid acetylators, 37 possessed at least one wild type allele; a 95% concordance with genotype. Seven different NAT2 alleles associated with slow acetylation were found. The commonest was aNAT2*5 type (C481T) allele which occurred with a frequency of 0.53, a significantly higher frequency than has been reported for other ethnic groups. A second slow allele, aNAT2*6 type (G590A), occurred with a frequency of 0.21. The most common genotypes found wereNAT2*5/*5 homozygotes,NAT2*5/*6 heterozygotes andNAT2*4/*5 heterozygotes with frequencies of 0.25, 0.25 and 0.22 respectively. The high overall prevalence of alleles associated with slow acetylation (173/212; 81.6%) among Emiratis is consistent with previously reported high frequency of the slow acetylator phenotype in Arabs. Two apparently new slow alleles were identified but have not yet been fully characterized. One appears to be aNAT2*5 variant allele. The other uncharacterized allele appears likely to contain an entirely new mutation associated with slow acetylation.
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