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Effect of Methotrexate on Folate Binding to a Folate Binding Protein in Cow's Milk

 

作者: Jan Holm,   Steen Ingemann Hansen,   Jørgen Lyngbye,  

 

期刊: Acta Pharmacologica et Toxicologica  （WILEY Available online 1978）
卷期: Volume 42, issue 1  

页码: 77-80

 

ISSN:0001-6683

 

年代: 1978

 

DOI:10.1111/j.1600-0773.1978.tb02172.x

 

出版商: Blackwell Publishing Ltd

 

关键词: Competitive inhibition;cooperativity;equilibrium dialysis;folate;ion exchange chromatography;ligand binding;methotrexate;cow

 

数据来源: WILEY

 

摘要:

AbstractFolate in cow's milk was strongly bound to a minor whey protein. Methotrexate inhibited the folate binding in a log dosis dependent manner, but was a rather weak inhibitor. The binding mechanism of folate changed from a cooperative to a non‐cooperative type in the presence of methotrexate. This model system could be used in investigations on human body fluids and tissue

 

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