Reduced Anesthetic Requirement after Electrical Stimulation of Periaqueductal Gray Matter
作者:
Michael Roizen,
Philippa Newfield,
Edmond Eger,
Yoshio Hosobuchi,
John Adams,
Sharon Lamb,
期刊:
Anesthesiology
(OVID Available online 1985)
卷期:
Volume 62,
issue 2
页码: 120-123
ISSN:0003-3022
年代: 1985
出版商: OVID
关键词: Analgesia.;Brain: brain stem; periaqueductal gray matter.;Pain.;Potency, anesthesic: MAC.
数据来源: OVID
摘要:
To determine whether electrical stimulation of the periaqueductal gray region decreases anesthetic requirement, the authors studied the effect of such stimulation on the MAC of halothane and 60% nitrous oxide in 33 patients. These patients, who were undergoing implantation of a radio-frequency-coupled receiver and connection of that receiver to electrodes previously implanted in the periaqueductal gray area, were assigned randomly to receive (n = 16) or not receive (n = 17) electrical stimulation 1 h before surgery. The mean value (±SEM) for the minimum alveolar concentration of halothane combined with 60% nitrous oxide was significantly less (P, < 0.001) for patients who were stimulated preoperatively (0.15 ± 0.05%) than for those who were not (0.51 ± 0.02%). The authors conclude that stimulation of the periaqueductal gray region decreases anesthetic requirements and believe that at least three mechanisms are possible: a nonspecific narcotic-like effect, a specific effect on a pain pathway, or an effect on specific neural pathways that affect anesthetic requirements secondary to changes in regional concentrations of neurotransmitters.
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