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A Rapid Aqueous Phase Preparation Procedure for131I-Labelled Meta-Iodobenzylguanidine (MIBG)

 

作者: G. Wollny,   U. Welzel,  

 

期刊: Isotopenpraxis Isotopes in Environmental and Health Studies  （Taylor Available online 1990）
卷期: Volume 26, issue 4  

页码: 150-151

 

ISSN:0021-1915

 

年代: 1990

 

DOI:10.1080/10256019008624262

 

出版商: Taylor & Francis Group

 

关键词: chemical reaction yield;deiodination;guanidins;impurities;iodine 131;labelled compounds;labelling;productivity;radiopharmaceuticals

 

数据来源: Taylor

 

摘要:

The process for catalytic radioiodine labelling of m-iodobenzyglunidine is described. This labelling procedure will be used in the routine-production process. A radiochemical yield below 80% is obtained at 100°C within 15 min. Separating unbonded iodine−131I the radiochemical purity is more than 98‰. After labelling the solution is made isotonic and brought on a pH of 5.5–6.5. By sterile filtration an injectable solution is obtained.

 

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