Induction of Interleukin 6 Synthesis in Mouse Glomeruli and Cultured Mesangial Cells
作者:
Masayuki Iwano,
Kazuhiro Dohi,
Eiji Hirata,
Yasuhiro Horii,
Hideo Shiiki,
Hyoe Ishikawa,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 1
页码: 58-65
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186996
出版商: S. Karger AG
关键词: Cultured mesangial cells;Cytokine;Experimental glomerulonephritis;Interleukin 1;Interleukin 6;Lipopolysaccharide;BSA nephritis;MRL-lpr mice
数据来源: Karger
摘要:
Interleukin 6 (IL-6) is an autocrine growth factor of cultured mesangial cells (MC) and intraglomerular IL-6 production is suggested to be closely associated with the pathogenesis of human mesangial proliferative glomerulonephritis (mesPGN). In this study, to elucidate the mechanisms regulating the intraglomerular production of IL-6, we examined what kinds of stimuli are significant in the induction of IL-6 synthesis in vitro and in vivo. Incubation of cultured mesangial cells with interleukin 1 (IL-1) or bacterial lipopolysaccharide (LPS) induced significant IL-6 production, and intravenous injection of IL-1 or LPS into normal BALB/c mice induced significant intraglomerular IL-6 mRNA expression. Furthermore, we indicated in this study that IL-6 mRNA expression was augmented in the glomeruli of mice with immune complex-mediated glomerulonephritis.
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